Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence
Abstract The endocannabinoid signalling system (ECS) plays a critical role from the very beginning of embryogenesis. Accordingly, the ECS is…
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Cannabidiol inhibits transient receptor potential canonical 4 and modulates excitability of pyramidal neurons in mPFC
Abstract Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, has been extensively studied for its potential therapeutic effects…
Preferences for Starting Daily, On-Demand, and Long-Acting Injectable HIV Preexposure Prophylaxis Among Men Who Have Sex With Men in the United States (2021-2022): Nationwide Online Cross-Sectional Study
Abstract Background: Long-acting (LA) injectable preexposure prophylaxis (PrEP) and on-demand PrEP may improve overall PrEP uptake among men who have…
The Correlation of Bile Duct Dilatation in Postmortem Computed Tomography of Lethal Intoxication Cases for Different Drug Types—A Retrospective Study
Abstract Purpose: To assess (I) whether, in autopsy-proven lethal intoxications with opiates/opioids, a dilatation of the common bile duct (CBD)…
Harnessing the healing power of nature: a review of natural interventions in substance abuse treatment and prevention
Abstract Background: Substance abuse is a global problem that cuts across all sectors of society and requires innovative solutions that…
Targeting carbohydrate metabolism in colorectal cancer – synergy between DNA-damaging agents, cannabinoids, and intermittent serum starvation
Abstract Chemotherapy is a therapy of choice for many cancers. However, it is often inefficient for long-term patient survival and…
A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats
Abstract Medicinal cannabis is being used worldwide and there is increasing use of novel cannabis products in the community. Cannabis…
UHPLC‐QTOFMS Urine Drug Screening With Dilute‐and‐Shoot Sample Preparation and Vacuum‐Insulated Probe‐Heated Electrospray Ionization
Abstract We developed a method for comprehensive urine drug screening by applying dilute‐and‐shoot extraction and vacuum‐insulated probe‐heated electrospray ionization with…
A Personalized Data Dashboard to Improve Compliance with Ecological Momentary Assessments in College Students: Protocol for a Microrandomized Trial
Abstract Background: Ecological momentary assessments (EMA) are ideal for capturing the dynamic nature of young adult substance use behavior in…
New Insights into the Development of Donepezil-Based Hybrid and Natural Molecules as Multi-Target Drug Agents for Alzheimer’s Disease Treatment
Abstract Alzheimer’s disease (AD) involves a complex pathophysiology with multiple interconnected subpathologies, including protein aggregation, impaired neurotransmission, oxidative stress, and…