Metabolic Responses of Melanocytes and Melanoma Cells to UVA Radiation and Phytocannabinoids Exposure
Abstract Ultraviolet A (UVA) radiation disrupts the redox balance of melanocytes and may lead to the development of melanoma, highlighting…
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Selected Cannabinoids, Cannabimimetic Agents and Artemisia Combinations as Theoretical Adjunct Strategies Against COVID-19
Abstract COVID-19 has spurred much interest in complementary and alternative agents for therapeutic purposes having antiviral and immunomodulatory effects. In…
Ureic clearance granule ameliorates chronic kidney disease by reshaping microbial dysbiosis via modulating bile acid metabolism
Abstract Background: Chronic kidney disease (CKD) is a highly prevalent global public health problem that inevitably leads to renal failure.…
Non-Psychoactive Cannabis Extract Disrupts Reinstatement and Reconsolidation in Cocaine-Induced Conditioned Place Preference in Mice
Abstract Highlights: What are the main findings? What are the implications of the main findings? Abstract: Background: Cocaine use disorder…
Enhancing anandamide signalling through fatty acid amide hydrolase inhibition: An update on the pharmacological strategy for treating psychiatric disorders
Abstract Endocannabinoids (eCBs) are lipid-derived neuromodulators that regulate numerous neurophysiological processes by modulating synaptic transmission. Synthesised on demand in response…
High-dose cannabidiol for chronic neuropathic pain associated with spinal cord injury: a randomised clinical trial
Abstract Background: Chronic neuropathic pain is common after spinal cord injury (SCI), yet current treatments have limited efficacy and significant…
Navigating dose-effect complexities and challenges in cannabinoid therapy for aging-related neurobiological changes
Abstract Growing evidence shows that brain aging is a time-dependent process, with very complex underlying mechanisms at molecular and cellular…
Glycyrrhiza uralensis-Atractylodes macrocephala combination supplementation enhances broiler growth performance, immunity, and intestinal health, potentially mediated through gut microbiota and metabolites
Abstract The poultry industry requires effective antibiotic alternatives to enhance growth and maintain health. This study investigated the effects of…
Glucagon-like peptide-1 receptor (GLP-1R) overexpression defines a distinct immunogenetic subset in primary and metastatic thyroid cancer: implications for GLP-1R agonist therapy
Abstract Introduction: The surge in prescribing glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for diabetes and weight management highlights a pressing…
Canine Idiopathic Epilepsy as a Natural Animal Model for Human Epilepsy: A Scoping Review Highlighting Metabolic Perspectives Beyond the Brain
Abstract Background: Emerging evidence indicates that epilepsy extends beyond the brain, involving systemic metabolic, immune, and microbiome perturbations that shape…