Cannabidiol polarizes human neutrophils toward a cancer-promoting phenotype
Abstract Introduction: Cannabidiol (CBD) is widely used as a natural alternative supplementary treatment for side effects and symptom relief in…
Free
Phytocannabinoids as Novel SGLT2 Modulators for Renal Glucose Reabsorption in Type 2 Diabetes Management
Abstract Background: Sodium–glucose cotransporter 2 (SGLT2) inhibitors have transformed type 2 diabetes mellitus (T2DM) management by promoting glucosuria, lowering glycated…
Molecular docking of danuglipron uncovers potential crossovers between GLP-1R and the endocannabinoid system
Abstract The targeting of the G-protein coupled receptor (GPCRs) glucagon-like-peptide-1-receptor (GLP-1R) by weight loss medications has become extremely prevalent due…
UGT2B7-mediated drug–drug interaction between cannabinoids and hydromorphone
Abstract Hydromorphone is a highly potent opioid used to treat severe chronic pain. It is metabolized primarily by UDP-glucuronosyltransferase (UGT)2B7…
The Role of the Endocannabinoid System in Oncology and the Potential Use of Cannabis Derivatives for Cancer Management in Companion Animals
Abstract Companion animals are more and more becoming considered family members, and their owners wish to offer them the same…
Phytochemical Modulators of Nociception: A Review of Cannabis Terpenes in Chronic Pain Syndromes
Abstract Cannabis sativa L. is a phytochemically rich plant with therapeutic potential across various clinical domains, including pain, inflammation, and…
Influence of Plant-Based Substrate Composition and Extraction Method on Accumulation of Bioactive Compounds in Hericium erinaceus (Bull.) Pers. Fruiting Bodies
Abstract The selection of plant-based substrates for mushroom cultivation is a key factor influencing their growth and metabolism. The aim…
Stereoselective Synthesis of Cannabidiol and its Unnatural Enantiomer to Evaluate Anxiolytic‐Like Properties and Memory Interactions
Abstract (−)‐Cannabidiol (CBD) is a nonpsychotropic phytocannabinoid found in Cannabis strains with well‐established pharmacological applications. Conversely, (+)‐cannabidiol (ent‐CBD), the non‐natural…
Medicinal cannabis for symptom control in advanced cancer: a double-blind, placebo-controlled, randomised clinical trial of 1:1 tetrahydrocannabinol and cannabidiol
Abstract Purpose: Patients with cancer commonly access cannabis hoping to relieve their symptoms. This study assessed whether a 1:1 10…
Hybrid Cannabis sativa L. inflorescences exert an anti-inflammatory effect through the modulation of MAPK/NF-κB/NLRP3 inflammasome and JAK1/STAT6 pathway in HaCaT cells
Abstract Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied by severe itching. Reducing mediators of skin inflammation…