EphA2-targeted alpha-particle theranostics for enhancing PDAC treatment
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) presents a formidable challenge in oncology due to its aggressive nature and resistance to…
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In vitro metabolism of Benzyl-4CN-BUTINACA and MDMB-4CN-BUTINACA using human hepatocytes and LC-QToF-MS analysis
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00204-025-04018-y. Article type: Research Article Keywords: New psychoactive substances,…
An Outbreak of Synthetic Cannabinoid-Adulterated Tianeptine Products in New Jersey – Case Series
Abstract Background: Tianeptine, an atypical antidepressant not approved in the United States, is readily purchased from unregulated markets such as…
Rastafarianism: When Religious Beliefs Conflict With Medical Necessity—A Case Report and Review of the Literature Around an Ethically Complicated Case
Abstract Background: Rastafarianism maintains that cannabis is a sacred element of the religious practice, and followers of the religion traditionally…
Management of Mirizzi Syndrome Type I: A Case Report
Abstract Mirizzi syndrome is a rare yet clinically significant condition characterized by mechanical obstruction of the common bile duct (CBD)…
Case Report: Cannabis and kratom-induced self-amputation of ears and penis
Abstract This report describes the case of a 31-year-old male lumberjack with severe self-inflicted injuries, including the amputation of both…
Clinical profiling and medical management of Israeli individuals with Phelan McDermid syndrome
Abstract Background: Phelan–McDermid syndrome (PMS) is a neurodevelopmental disorder, caused by haploinsufficiency of the SHANK3 gene. In addition to global…
Utilization of medicinal hemp: a qualitative analysis of clinicians’ perspectives in Ghana
Abstract Background: Previous studies have explored the perspectives of health care professionals on the use of medicinal hemp, but they…
Efficacy and Safety of Cannabinoids for Autism Spectrum Disorder: An Updated Systematic Review
Abstract Autism Spectrum Disorder (ASD) lacks an established pharmacological treatment protocol, prompting interest in alternative therapeutic approaches, such as cannabidiol…
The efficacy of cannabidiol for seizures reduction in pharmacoresistant epilepsy: a systematic review and meta-analysis
Abstract Background: Epilepsy is a neurological syndrome caused by excessive neuronal discharges, with a part of the patients being pharmacoresistant…