The CB1 receptor: linking impulsivity and substance use disorder
Abstract The cannabinoid receptor type 1 (CB1R) is the most widely expressed G protein-coupled receptor in the brain, with high…
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Waldo: Automated discovery of adverse events from unstructured self reports
Abstract Adverse event (AE) detection is labor-intensive and costly given the task is to find rare events. Automated solutions to…
Preclinical assessment of pharmacokinetics and anticonvulsant activity of CBDTech, a novel orally administered cannabidiol (CBD) formulation for seizure and epilepsy
Abstract Oral cannabidiol (CBD) product use is increasing despite suboptimal pharmacokinetics (PK) of currently available formulations. This study aimed to…
Effect of intraperitoneal cannabidiol (CBD) injection on intestine microbiome profile in a mouse model
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00294-025-01327-8. Article type: Research Article Keywords: Cannabidiol, Microbiome, 16S…
Driving and cannabis use: a questionnaire about knowledge and behaviors after the legalization of recreational cannabis in California
Abstract Background: Implemented in 2018, Proposition 64: The Adult Use of Marijuana Act legalized recreational cannabis use in California. This…
Rural inpatient hospitals and substance use—a 10-year retrospective analysis
Abstract Aim: To determine the burden and nature of substance use presentations within a defined rural region and provide an…
New insights into the crosstalk between endocannabinoids and sphingosine-1-phosphate
Abstract This review aims at highlighting the interplay between the endocannabinoids (eCBs) anandamide and 2-arachidonoylglycerol and sphingosine-1-phosphate (S1P) signaling. The…
Global Influence of Cannabis Legalization on Social Media Discourse: Mixed Methods Study
Abstract Background: Cannabis is the third most consumed drug worldwide, with its use linked to a high number of substance…
ABCB1 polymorphisms are associated with clinical response to nabiximols in patients with multiple sclerosis-related spasticity
Keywords: Multiple sclerosis, Single nucleotide polymorphisms, Nabiximols, Spasticity, ABCB1 Authors: Alessandra Gemma, Marco Mauri, Paola Banfi, Maurizio Versino, Alen Zollo,…
Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial
Abstract Chronic low back pain (CLBP) affects over half a billion people worldwide. Current pharmacologic treatments offer limited efficacy and…