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Research linked to this compound
3 rights-cleared articles, ordered newest first.
Background Sintilimab-induced rash is a significant clinical challenge in lung cancer treatment, often necessitating therapy interruption or discontinuation and thereby compromising patient outcomes. The underlying mechanisms of this adverse event remain poorly understood. This study aimed to investigate potential predictive biomarkers and mechanisms of sintilimab-induced rash through metabolomic profiling. Method…
Despite of the scientific and human efforts to understand COVID-19, there are questions still unanswered. Variations in the metabolic reaction to SARS-CoV-2 infection could explain the striking differences in the susceptibility to infection and the risk of severe disease. Here, we used untargeted metabolomics to examine novel metabolic pathways related to SARS-CoV-2 susceptibility and COVID-19 clinical severity us…
Synthetic microbial communities are attractive for applied biotechnology and healthcare applications through their ability to efficiently partition complex metabolic functions. By pairing auxotrophic mutants in co-culture, nascent E. coli communities can be established where strain pairs are metabolically coupled. Intuitive synthetic communities have been demonstrated, but the full space of cross-feeding metabolit…