Plant cannabinoids

11-Nor-9-carboxy-Delta(9)-tetrahydrocannabinol

A phytocannabinoid that is Δ9-tetrahydrocannabinol in which the C-11 methyl has been fully oxidised to a carboxy group. Further enzymatic oxidation product of 11-hydroxy-Δ9-tetrahydrocannabinol.

Definition: CHEBI:77273 · Chemical Entities of Biological Interest · release 253

53public articles

2registered condition areas

All documents →

Identity & provenance

Chemical identity

C21H28O4 · molecular weight 344.451

Sources: ChEBI · 253 PubChem computed properties · pug-221918c3894d8eda

0 referenced plant-occurrence records. They are identity candidates, not clinical evidence.

Research areas

Conditions found alongside this compound

Document links and organism occurrence are candidates, not proof of efficacy, safety or a treatment recommendation.

Chronic pain and cannabinoids

1 matching public articles

Candidate association · not a treatment claim

Multiple sclerosis and cannabinoids

1 matching public articles

Candidate association · not a treatment claim

Linked local records

Medicines and registered studies

Links use source-reported active ingredients or study intervention names and remain candidates, not treatment claims.

Medicines with this active ingredient

No public medicine record matched.

Registered studies

0 exact source-intervention matches.

No registered study intervention matched.

Recent research

2026

Validation of a microsampling-compatible liquid-liquid extraction method for cannabinoid quantitation in 50 µL of whole blood using liquid chromatography-mass spectrometry.

Journal of Analytical Toxicology · Free full text · non-commercial reuse

2026

Breast milk Δ9-tetrahydrocannabinol in cannabis users during the postpartum period: correlation between breast milk, maternal urine and saliva samples during early lactation

Frontiers in Psychiatry · Free full text

2026

Prevalence and characteristics of prenatal cannabis use in Michigan, USA: A statewide population-based pregnancy cohort.

Addiction (Abingdon, England) · Free full text

2026

Recent cannabis exposure and acute nicotine effects: insights from randomized, double-blind, placebo-controlled intravenous nicotine studies

International Journal of Neuropsychopharmacology · Free full text

2026

The acute and chronic pharmacokinetics and pharmacodynamics of oral cannabidiol with and without low doses of delta-9-tetrahydrocannabinol.

Journal of Analytical Toxicology · Free full text · non-commercial reuse

2026

Cognitive performance and subjective effects the morning after last use of smoked cannabis by adults who use cannabis frequently: An observational study.

Drug and Alcohol Dependence Reports · Free full text · non-commercial reuse

11-Nor-9-carboxy-Delta(9)-tetrahydrocannabinol

Chemical identity

Conditions found alongside this compound

Chronic pain and cannabinoids

Multiple sclerosis and cannabinoids

Medicines and registered studies

Medicines with this active ingredient

Registered studies

Recent research

Validation of a microsampling-compatible liquid-liquid extraction method for cannabinoid quantitation in 50 µL of whole blood using liquid chromatography-mass spectrometry.

Breast milk Δ9-tetrahydrocannabinol in cannabis users during the postpartum period: correlation between breast milk, maternal urine and saliva samples during early lactation

Prevalence and characteristics of prenatal cannabis use in Michigan, USA: A statewide population-based pregnancy cohort.

Recent cannabis exposure and acute nicotine effects: insights from randomized, double-blind, placebo-controlled intravenous nicotine studies

The acute and chronic pharmacokinetics and pharmacodynamics of oral cannabidiol with and without low doses of delta-9-tetrahydrocannabinol.

Cognitive performance and subjective effects the morning after last use of smoked cannabis by adults who use cannabis frequently: An observational study.

Impact of CBD and hemp oil use on drug test results: a systematic review.

A Sustainable Air-Assisted Liquid–Liquid Microextraction Procedure Coupled to Liquid Chromatography–Tandem Mass Spectrometry for the Determination of 11-Nor-9-carboxy-Δ9-tetrahydrocannabinol and Hexahydrocannabinol Metabolites in Urine

Pharmacokinetic/Pharmacodynamic Modeling of the Acute Heart Rate Effects of Delta-9 Tetrahydrocannabinol and Its Major Metabolites After Intravenous Injection in Healthy Volunteers.

Pharmacokinetics of cannabidiol, (-)-trans-Δ9-tetrahydrocannabinol, and their oxidative metabolites after intravenous and oral administration of a cannabidiol-dominant full-spectrum hemp product to beagle dogs.

Quantification of ∆9-tetrahydrocannabinol, 11-OH-THC, THC-COOH, hexahydrocannabinol, and cannabidiol in human plasma and blood by liquid chromatography-tandem mass spectrometry.

Quantitative and qualitative changes in substance-related administrative offences in road traffic during the SARS-CoV-2 pandemic in Munich.