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Research Article 2020CC BYFree full text

Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression.

Amira Mohammed, Hasan FK Alghetaa, Kathryn Miranda, Kiesha Wilson, Narendra P Singh, Guoshuai Cai +3 more

Acute Respiratory Distress Syndrome (ARDS) causes up to 40% mortality in humans and is difficult to treat. ARDS is also one of the major triggers of mortality associated with coronavirus-induced disease (COVID-19). We used a mouse model of ARDS induced by Staphylococcal enterotoxin B (SEB), which triggers 100% mortality, to investigate the mechanisms through which Δ9-tetrahydrocannabinol (THC) attenuates ARDS. SEB…

International Journal of Molecular Sciences Europe PMC

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Research Article 2011CC0Free full text

Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol.

Venkatesh L. Hegde, Prakash S. Nagarkatti, Mitzi Nagarkatti

Background Myeloid-derived suppressor cells (MDSCs) are getting increased attention as one of the main regulatory cells of the immune system. They are induced at sites of inflammation and can potently suppress T cell functions. In the current study, we demonstrate how activation of TRPV1 vanilloid receptors can trigger MDSCs, which in turn, can inhibit inflammation and hepatitis. Methodology/principal findings Pol…

PLoS ONE Europe PMC

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