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19172026

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Author: Sheikh Tasduq Abdullah

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Research Article 2026CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Discovery of a novel cannabidiol-derived transient receptor potential vanilloid 4 inhibitor to reduce pulmonary edema and lung vascular permeability in mice.

Yassir Arfath, Pankaj Singh Cham, Tusharika Kotra, Rahila Akhter, Sumeer Ahmed, Mandeep Kour +4 more

Introduction Activation of TRPV4 ion channel during acute lung injury (ALI) exacerbates lung dysfunction by promoting edema and inflammation. Pharmacological inhibition of TRPV4 signaling in the lungs offers protective benefits, reducing vascular leakage, enhancing blood oxygenation, and alleviating edema. Objectives We designed, synthesized, and preclinically evaluated cannabidiol-derived TRPV4 channel inhibitors…

TRPV4 Inflammation ALI Ca2+Cannabidiol Edema Vascular permeability

Cellular & Molecular Biology Letters PubMed Central Open Access↗

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