Readable research linked to original sources

Articles

Browse normalized, publication-ready research with direct links to its evidence and source.

2 articles

Newest first

Research Article 2023-10-13CC BYFree full text

Mendelian randomization revealing the protective effect of sodium-glucose cotransporter 2 inhibition on prostate cancer with verified evidence from electronic healthcare and biological data

Jie Zheng, Jieli Lu, Jiying Qi, Qian Yang, Huiling Zhao, Haoyu Liu +29 more

BackgroundObservational studies indicated a decreased risk of prostate cancer by SGLT2 inhibitors, but high-quality evidence is lacking to make a clear conclusion. We evaluated the effect of SGLT2 inhibition on prostate cancer risk by triangulating evidence from three methods. MethodsGenetic variants associated with HbA1c levels (P<5x10-8) in the genomic region of the target gene, SLC5A2, were used to proxy SGLT2…

medRxiv medRxiv

Open article record in new tab ↗

Research Article 2019-03-28CC BYFree full text

The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank

Padraig Dixon, William Hollingworth, Sean Harrison, Neil M Davies, George Davey Smith

Estimates of the marginal effect of measures of adiposity such as body mass index (BMI) on healthcare costs are important for the formulation and evaluation of policies targeting adverse weight profiles. Many existing estimates of this association are affected by endogeneity bias caused by simultaneity, measurement error and omitted variables. The contribution of this study is to avoid this bias by using a novel i…

bioRxiv bioRxiv

Open article record in new tab ↗