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Research Article 2021-12-24CC BYFree full text

SARS-CoV-2 vaccine Alpha and Delta variant breakthrough infections are rare and mild, but happen relative early after vaccination

Jelissa Katharina Peter, Fanny Wegner, Severin Gsponer, Fabrice Helfenstein, Tim Roloff, Rahel Tarnutzer +22 more

IntroductionCOVID-19 vaccines significantly reduce SARS-CoV-2 (SCoV2)-related hospitalization and mortality in randomized controlled clinical trials, as well as in real-world effectiveness against different circulating SCoV2-lineages. However, some vaccine recipients show breakthrough infection and it remains unknown, which host and viral factors contribute to this risk and how many resulted in severe outcomes. Ou…

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Research Article 2021-06-21CC BY-NCFree full text · non-commercial reuse

Determinants of SARS-CoV-2 transmission to guide vaccination strategy in a city

Sarah C. Brüningk, Juliane Klatt, Madlen Stange, Alfredo Mari, Myrta Brunner, Tim-Christoph Roloff +25 more

BackgroundTransmission chains within small urban areas (accommodating[~]30% of the European population) greatly contribute to case burden and economic impact during the ongoing COVID-19 pandemic, and should be a focus for preventive measures to achieve containment. Here, at very high spatio-temporal resolution, we analysed determinants of SARS-CoV-2 transmission in a European urban area, Basel-City (Switzerland).…

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