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Research Article 2022CC BYFree full text

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci

Joseph D. Deak, Hang Zhou, Marco Galimberti, Daniel F. Levey, Frank R. Wendt, Sandra Sanchez-Roige +14 more

Despite the large toll of opioid use disorder (OUD), genome-wide association studies (GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale GWAS of OUD in individuals of European (EUR) and African (AFR) ancestry, optimizing genetic informativeness by performing MTAG (Multi-trait analysis of GWAS) with genetically correlated substance use disorders (SUDs). Meta-analysis included seve…

Molecular Psychiatry PubMed Central Open Access

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Research Article 2022-01-12CC BY-NCFree full text · non-commercial reuse

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Alexander S. Hatoum, Sarah M.C. Colbert, Emma C. Johnson, Spencer B. Huggett, Joseph D. Deak, Gita Pathak +17 more

Genetic liability to substance use disorders can be parsed into loci conferring general and substance-specific addiction risk. We report a multivariate genome-wide association study that disaggregates general and substance-specific loci for problematic alcohol use, problematic tobacco use, and cannabis and opioid use disorders in a sample of 1,025,550 individuals of European and 92,630 individuals of African desce…

medRxiv medRxiv

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