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19172026

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Author: Maria A Deli

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Research Article 2020CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Drug-Resistant Temporal Lobe Epilepsy Alters the Expression and Functional Coupling to Gαi/o Proteins of CB1 and CB2 Receptors in the Microvasculature of the Human Brain.

María de los Ángeles Nuñez-Lumbreras, José Luis Castañeda-Cabral, María Guadalupe Valle-Dorado, Vicente Sánchez-Valle, Sandra Orozco-Suárez, Rosalinda Guevara-Guzmán +6 more

Cannabinoid receptors 1 and 2 (CB1 and CB2, respectively) play an important role in maintaining the integrity of the blood-brain barrier (BBB). On the other hand, BBB dysfunction is a common feature in drug-resistant epilepsy. The focus of the present study was to characterize protein expression levels and Gαi/o protein-induced activation by CB1 and CB2 receptors in the microvascular endothelial cells (MECs) isola…

Frontiers in Behavioral Neuroscience Europe PMC↗

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