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Research Article 2023-03-15CC BYFree full text

Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection

Thandeka Moyo-Gwete, Simone I. Richardson, Roanne Keeton, Tandile Hermanus, Holly Spencer, Nelia P. Manamela +19 more

The impact of previous SARS-CoV-2 infection on the durability of Ad26.COV2.S vaccine-elicited responses, and the effect of homologous boosting has not been well explored. We followed a cohort of healthcare workers for 6 months after receiving the Ad26.COV2.S vaccine and a further one month after they received an Ad26.COV2.S booster dose. We assessed longitudinal spike-specific antibody and T cell responses in indi…

medRxiv medRxiv

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Research Article 2021CC0Free full text

Benign ethnic neutropenia in a South African population, and its association with HIV acquisition and adverse event reporting in an HIV vaccine clinical trial.

Rephaim Mpofu, Kennedy Otwombe, Koleka Mlisana, Maphoshane Nchabeleng, Mary Allen, James Kublin +5 more

Benign ethnic neutropenia (BEN) is defined as a neutrophil count of <1.5×109 cells/L in healthy individuals and is more common in populations of certain ethnicities, e.g. African or Middle Eastern ethnicity. Neutrophil values are commonly included in eligibility criteria for research participation, but little is known about the relationship between BEN, HIV acquisition, and the occurrence of adverse events during…

PLoS ONE PubMed Central Open Access

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