Readable research linked to original sources

Articles

Browse normalized, publication-ready research with direct links to its evidence and source.

2 articles

Newest first

Research Article 2026-02-07CC BYFree full text

Protocol for the development of a tool (INSPECT-IPD) to identify problematic randomised controlled trials when individual participant data are available

Calvin Heal, Lisa Bero, George A. Antoniou, Nicole Au, Amir Aviram, Vincenzo Berghella +26 more

IntroductionRandomised controlled trials (RCTs) investigate the safety and efficacy of interventions. It has become clear however that some RCTs include fabricated data. The INSPECT-SR tool assesses the trustworthiness of RCTs in systematic reviews of healthcare-related interventions. However, where individual participant data (IPD) can be obtained, a more thorough assessment of trustworthiness is possible. Conseq…

medRxiv medRxiv

Open article record in new tab ↗

Research Article 2025-01-06CC BYFree full text

Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project

Jack Wilkinson, Calvin Heal, Georgios A Antoniou, Ella Flemyng, Love Ahnström, Alessandra Alteri +60 more

BackgroundThe aim of the INSPECT-SR project is to develop a tool to identify problematic RCTs in systematic reviews. In Stage 1 of the project, a list of potential trustworthiness checks was created. The checks on this list must be evaluated to determine which should be included in the INSPECT-SR tool. MethodsWe attempted to apply 72 trustworthiness checks to RCTs in 50 Cochrane Reviews. For each, we recorded whet…

medRxiv medRxiv

Open article record in new tab ↗