Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
3 articles
Newest firstBackgroundThe number of problematic randomized clinical trials (RCTs) has risen sharply in recent decades, posing serious challenges to the integrity of the healthcare evidence ecosystem. ObjectiveTo investigate whether retraction of problematic RCTs could reduce evidence contamination. DesignRetrospective cohort study SettingA secondary analysis of the VITALITY Study database. Participants1,330 retracted RCTs wit…
Open article record in new tab ↗BackgroundThe aim of the INSPECT-SR project is to develop a tool to identify problematic RCTs in systematic reviews. In Stage 1 of the project, a list of potential trustworthiness checks was created. The checks on this list must be evaluated to determine which should be included in the INSPECT-SR tool. MethodsWe attempted to apply 72 trustworthiness checks to RCTs in 50 Cochrane Reviews. For each, we recorded whet…
Open article record in new tab ↗IntroductionRandomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and some appear to have been entirely fabricated. Systematic reviews are performed to identify and synthesise all RCTs that have been conducted on a given topic. While it is usual to assess methodological features of the RCTs in the process of undertaking a systematic review,…
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