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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
4 articles
Newest firstHealthcare systems must balance rising costs with the delivery of effective care, yet the factors underlying large inter-individual differences in healthcare expenditure remain incompletely understood. Here we examine how genome-wide genetic variation contributes to healthcare costs, analysing inpatient, outpatient, primary care and prescription drug expenditure in up to 1,429,889 individuals from 11 studies acros…
Open article record in new tab ↗Electronic health record (EHR)-based phenotype risk scores (PheRS) leverage individuals health trajectories to infer disease risk. Similarly, polygenic scores (PGS) use genetic information to estimate disease risk. While PGS generalizability has been previously studied, less is known about PheRS transferability across healthcare systems and whether PheRS provide complementary risk information to PGS. We trained Ph…
Open article record in new tab ↗BackgroundAccurately predicting short-term mortality is important for optimizing healthcare resource allocation, developing risk-reducing interventions, and improving end-of-life care. Moreover, short-term mortality risk reflects individual frailty and can serve as digital aging marker. Previous studies have focused on specific, high-risk populations. Predicting all-cause mortality in an unselected population inco…
Open article record in new tab ↗BackgroundA critical step in evaluating healthcare interventions is to understand their impact on healthcare costs. However, there is a limited understanding of the causal impact that biomarkers and risk factors for disease have on healthcare-related costs. Previous studies based on observational data have major limitations including residual confounding and reverse causation. Here, we used a genetically-informed…
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