Schizophrenia is one of the major contributors to the global burden of disease. Several factors have been recognized to be involved in the onset of neurodevelopmental disease, including exposure of the fetus viral influenza, rubella, or maternal toxoplasmosis [4, 15–17]. In addition, other studies have demonstrated the effect of the interaction between environmental and genetic factors [18, 19]. As a result, the explanatory model of schizophrenia appears complex like any multifactorial disease [18]. Beyond these assumptions, schizophrenia is recognized as a ubiquitous pathology whose appearance seems to be linked to individual’s age and sex. This is corroborated by the fact that the disease is most often observed in boys between 15 and 24 years old and girls between 25 and 35 years old [20]. The results of the present study showed that schizophrenia was more common in males than in females. Aleman et al. confirmed evidence for gender difference in the risk of developing schizophrenia [21]. Previous investigations have reported evidence that the gender difference in schizophrenia reflects differences both in neurodevelopmental processes and in social effects on risk and disease course [22]. Markham et al. also suggested a protective role of ovarian hormones against the onset of schizophrenia [22]. Gender inequality seems to be confirmed for the Malian population. Indeed, among the patients in hospital psychiatric care in Mali, we find the predominance of the male gender and especially the 23–25 age group [23–25]. The 25 to 34 age group was the most represented in our study. These results were comparable to those reported by Esan et al. who found that the majority of patients diagnosed with schizophrenia in the Southwest Nigerian population were 25–34 years old [11]. Weiser and al. and Mounkoro et al. found similar trend with the 25–35 age group [25, 26]. Although a small number of cases of schizophrenia appear after age 40, the majority of cases of schizophrenia occur in adolescence [27]. Mental health disorders like schizophrenia are exacerbated by the lack of structured and working activities for young people. Thus, the unemployed were the most represented in our study sample. This trend has also been observed in some studies carried out by Houngbé et al., Kelede et al. and Marwaha et al., in which significantly high prevalence of schizophrenia were observed among the unemployed in Benin, Ethiopia and the United Kingdom [27–29]. The link between the increased risk of schizophrenia and social disadvantages such as the high unemployment rate has been confirmed by other studies [7]. Generally speaking the lack of work and social support leads to a loss of personality and social independence in many young people, constituting an obstacle to the realization of their dreams. Marital status, in particular single status, has been reported to influence the course of schizophrenia (from onset of the prodrome to subsequent outcome). In our study, single people were more represented in the schizophrenic population. This trend has also been observed in the Ethiopian population, where Kebede et al. found that people who never married had a 3-folds higher risk of developing schizophrenia compared to married people. In addition, they found that the risk of the disease was 6 times higher in individuals who were separated, divorced or widowed [28]. In a review, Messias and al. also reported that unmarried people are 4 times more likely to develop schizophrenia than married people [1]. Factors such as relationship avoidance, inability to start or maintain a long-term relationship can expose individual to develop schizophrenia [28]. In the African context, the celibacy of an adult or, even worse, an elderly person is an anomaly. It is perceived as a deviance that profoundly upsets cultural and social models. Celibacy could conceal serious emotional or relational suffering and social isolation. This is particularly true of the elderly who do not have offspring, leading to psychological discomfort. The relational vulnerability appears to affect divorced/separated and single individuals slightly more than couples or widowers. Our study did not reveal any statistical difference between education level of education and schizophrenia. These results were consistent with those of the Ethiopian and Tunisian communities [12, 28]. However, Luo et al. have reported lower risk of schizophrenia among people with additional years of study in the Chinese population [30]. Improving the level of education can prevent schizophrenia. Urban birth is a well-known risk factor for developing schizophrenia and this was supported by certain studies which found that being a male and living in an urban area was an independent risk factor for schizophrenia in Ethiopia and Ireland [28, 31]. In addition, Lundberg et al. concluded that urban birth was associated with the schizophrenia delusions subgroup in the Uganda population [32]. It has also been reported in the population of Copenhagen that the risk of schizophrenia is high in people who lived their first 5 to 15 years in an urban setting [33]. A large meta-analysis including 46,820 cases of psychosis conducted mainly in the European population, revealed that the incidence of schizophrenia measured in terms of population size or density increases significantly in the urban areas compared to rural areas with an estimated risk level of 2.27 [34]. This makes it possible to consider urbanity as a “marker” of the risk of schizophrenia [20]. Our results have shown the same trend with a predominance of schizophrenics having for place of birth and first year of life the urban environment. The risk of schizophrenia increases with the degree of urbanization at birth and this may be linked to traffic, toxins, infections, diet, social class, or selective migration [34]. In the Malian context, our result could also be linked to a bias due to the offer of available psychiatric care. In fact, in Mali, psychiatric care is available in a single university hospital center in Bamako and four other outpatient units located in the administrative regions. The capacity and the resources allocated to these units are very limited. As a result, these ambulatory care units can only ensure continuity of patient care. The country has 0.05 psychiatrists for 1000,000 inhabitants. The frequencies of family (N = 83) and sporadic (N = 81) cases were statistically similar in our study sample. The same trend was observed in the Afrikaner population in South Africa by Van der Merwe et al., N = 149 versus N = 130 [10]. In the contrast, most cases of schizophrenia in the Taiwanese and Chinese populations were sporadic [35, 36]. The distribution of schizophrenia types may depend on the population studied, genetic background and environmental factors. The paranoid form was the most common form in our sample. Our results are consistent with those obtained by Campbell et al. [37]. In addition, a study by Stomp and al. using the DSM-IV and ICD-10 criteria showed a high rate of paranoid form and a low rate for hebephrenic and catatonic forms in the Austria population of Vienna [38]. On the other hand, undifferentiated forms were very frequent in the Tunisian population followed by Paranoid forms [39]. The first-born siblings were the most affected by schizophrenia in our study (31.1% of cases). Although, several studies have shown the predominance in the first-born, some authors recommend caution in suggesting a causal link [1, 40]. We found a consanguinity rate of 30.5% in schizophrenic patients. In Egypt, Mansour et al. reported a rate of 46.6% in the Nile Delta region [41]. McClain et al. considered inbreeding as an age-dependent risk factor for schizophrenia [13]. Bener et al. also showed in the Qatari population that parental consanguinity was high in schizophrenic patients (41.3%) than in non-schizophrenia controls (28.7%) [42]. However, inbreeding has not been associated with schizophrenia in the highly consanguineous Sudanese community [43]. The association of inbreeding with schizophrenia raises the possibility of general physiological decline and recessive genetic risk factors [44]. In the African context, inbreeding is more common among lower socioeconomic groups, which in turn can lead to a high prevalence of socio-cultural and environmental risk factors for schizophrenia, such as consanguineous marriages, obstetric complications, or exposure to putative causative infectious agents. Consanguineous marriage is allowed among the Malian population, but its prohibition in terms of likely public health benefits is debated in every family. Patients born during the cool season were the most represented with 48.8% of cases and 21.3% were born in the hot season and 18.9% during the rainy season. The relationship between birth in rainy period and schizophrenia was demonstrated in previous works [45, 46]. Several authors support this trend and several hypotheses have been put forward to explain the high frequency of this disease in the rainy season [44, 47, 48]. Among them, exposure to infectious agents, in particular the influenza virus, which is the best documented [26]. The notion of cannabis use was found in 32.3% of our schizophrenic patients and this frequency was higher than that observed in the Tunisian population (6.4%). Schizophrenia and cannabis use seems to have a close relationship. The role of tetrahydrocannabinol (THC) in the onset of psychosis and schizophrenia in the population at risk has already been suspected [49]. Our results also showed a strong representation of schizophrenic patients whose biological parents were unschooled. Cao et al. found that parental education level and childbearing age are associated with an increased risk of schizophrenia in a Chinese population [50].