Access to safe, effective, and affordable wound care is crucial for early healing and the overall well-being of patients [1–3]. From treating minor cuts to managing post-surgical wounds, proper dressing techniques help prevent infections and promote wound healing [4,5]. One important aspect of wound care is the type of gloves used during the procedure [6]. Sterile gloves are often preferred as the standard for wound care and minor surgical procedures because of their ability to protect against wound infections [7,8]. However, the use of sterile gloves in many low- and middle-income countries (LMICs) pose significant financial burden to both the health facility and the patient receiving care due to the high cost of the glove [9,10]. As a result, in the quest to meet sterile gloves demand, other aspects of care delivery may be compromised.

To meet the health needs of people without compromising the quality of care, the World Health Organization (WHO) has emphasized the importance of adapting medical guidelines to local realities, particularly in settings where high costs may limit access to quality care [11–13]. In such situations, the goal is to maintain or improve on the level of safety and quality while using more affordable alternatives. Therefore, if examination gloves can provide adequate protection during wound care at a fraction of the cost of sterile gloves, they could offer a valuable solution for under-resourced health systems striving to deliver quality care to all.

Although several systematic reviews have explored the effectiveness of sterile versus examination gloves in wound care and minor surgical procedures, there are limited studies that brought this evidence together in one comprehensive review. This study therefore aims to address that gap by conducting an overview of systematic reviews, bringing together findings from multiple high-quality systematic reviews to provide a clearer and broader understanding. It will evaluate both the care quality (infection prevention) and cost implications of using sterile versus examination gloves, to inform practical and evidence-based decisions in resource-limited settings. The findings will help guide healthcare providers and policymakers in choosing strategies that are both cost-efficient and safe for patients.