Developmental Deconvolution for Classification of Cancer Origin

Abstract An artificial intelligence classifier trained to distinguish the developmental profiles of different tumor types is applied to cancers of unknown primary, revealing diagnosis for each case. Authors: Enrico Moiso ⚬, Alexander Farahani ⚬, Hetal D. Marble ⚬, Austin Hendricks ⚬, Samuel Mildrum ⚬, Stuart Levine ⚬, Jochen K. Lennerz ⚬, Salil Garg ⚬ Affiliations: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts.; Broad Institute of Harvard-MIT, Cambridge, Massachusetts.; Department of Pathology, Massachusetts General Hospital,