Pan-cancer analysis reveals the roles of XPO1 in predicting prognosis and tumorigenesis

Abstract Background: Exportin 1 (XPO1), a nuclear export protein, participates in many biological processes, including mRNA transport, nucleocytoplasmic transport, nuclear protein export, regulation of mRNA stability, and drug response. XPO1 plays key roles in many cancer types and may serve as a potential biomarker. It is significant to systematically elucidate the roles of XPO1 in various cancer types in terms of function, molecular biology, immunology, and clinical relevance. Methods: Data from UCSC Xena, CCLE, and CBioPortal were analyzed for the