3,4,5-Trihydroxycinnamic acid exerts anti-inflammatory effects on TNF-α/IFN-γ-stimulated HaCaT cells

Abstract 3,4,5-Trihydroxycinnamic acid (THCA) exhibits anti-inflammatory activity in acute or chronic inflammatory disorders, such as acute lung injury and asthma. The present study investigated the anti-inflammatory activity of THCA in a tumor necrosis factor-α/interferon-γ (TI) mixture-stimulated human keratinocyte cell line. The results of ELISA and reverse transcription-quantitative PCR revealed that THCA reduced the secretion and mRNA expression levels of interleukin (IL)-6; IL-8; thymus and activation-regulated chemokine; macrophage-derived chemokine; regulated upon activation, normal T cell expressed and secreted; and monocyte chemoattractant