Identification of Tumor Tissue of Origin with RNA-Seq Data and Using Gradient Boosting Strategy

Abstract Background: Cancer of unknown primary (CUP) is a type of malignant tumor, which is histologically diagnosed as a metastatic carcinoma while the tissue-of-origin cannot be identified. CUP accounts for roughly 5% of all cancers. Traditional treatment for CUP is primarily broad-spectrum chemotherapy; however, the prognosis is relatively poor. Thus, it is of clinical importance to accurately infer the tissue-of-origin of CUP. Methods: We developed a gradient boosting framework to trace tissue-of-origin of 20 types of solid tumors. Specifically, we