Recruitment of CD103+ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy

Abstract Targeted delivery of CCL4 to the tumor stroma recruits CD103+ dendritic cells and enhances the efficacy of CPI immunotherapy. Authors: John-Michael Williford ⚬, Jun Ishihara ⚬, Ako Ishihara ⚬, Aslan Mansurov ⚬, Peyman Hosseinchi ⚬, Tiffany M. Marchell ⚬, Lambert Potin ⚬, Melody A. Swartz ⚬, Jeffrey A. Hubbell ⚬ Affiliations: Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA.; Institute of Bioengineering, Ecole Polytechnique Fédérale