Natural Photosensitizers in Cancer Therapy: A Chemo‐Biodiversity Perspective on Light‐Activated Natural Compounds

Abstract Natural photosensitizers have emerged as promising candidates for photodynamic therapy (PDT) owing to their structural diversity, favorable biocompatibility, and broad biological activities. However, their significance extends beyond their natural origin, as they represent the products of chemo‐biodiversity shaped by millions of years of evolutionary adaptation to diverse ecological pressures. This review examines natural photosensitizers through a chemo‐biodiversity perspective, emphasizing how evolutionary diversification has generated structurally distinct photoactive scaffolds with unique photophysical and photobiological properties relevant to cancer therapy. Attention