The KRT15 and KRT81 complex promotes lenvatinib resistance in thyroid cancer by upregulating DGKB mediated lipid metabolism

Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-47994-6. Article type: Research Article Keywords: Lenvatinib resistance, Thyroid cancer, KRT15, KRT81, DGKB, Lipid metabolism, Cancer, Endocrinology Authors: Yunjun Wang, Yu Zhang, Dan Zhao, Yi Wu, Tian Liao, Yu Wang, Jun Xiang, Qi Chen, Tuanqi Sun Affiliations: https://ror.org/00my25942grid.452404.30000 0004 1808 0942Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; https://ror.org/013q1eq08grid.8547.e0000 0001 0125 2443Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China License: © The