Synthesis of 2‐(Quinoxalin‐2‐yl)acetamides and Their Preliminary Cytotoxic and Antibacterial Activity

Abstract Quinoxaline is an aza‐heterocycle found in some bioactive compounds. Thus, to enhance the pharmacological scope of this nucleus, we report a series of 19 acetamides decorated with a quinoxaline core. The synthesis involved the linkage of previously constructed bromoacetamides and hydroxyphenyl quinoxalines via an SN2 reaction. The first series considered a 1,4‐substituted phenyl ring as a linker, and some derivatives showed moderate antibacterial activity against a panel of ESKAPE pathogens, especially against methicillin‐resistant Staphylococcus aureus (inhibition ranging from 10%