Investigating the expression of hsa_circ_0036722/hsa-miR-503-5p/PDCD4 axis in esophageal cancer

Abstract Background: Esophageal cancer (EC) is the ninth most common cancer globally. Circular RNAs (circRNAs), including hsa_circ_0036722, are important in various cancers, but their specific role in EC remains unclear. Therefore, this study investigates the roles of hsa_circ_0036722 in EC. Methods: We analyzed circRNAs sequencing from Gene Expression Omnibus (GEO). On the other hand, analyzed miRNAs and mRNAs sequencing related to EC from The Cancer Genome Atlas (TCGA). Then, the hsa_circ_0036722/hsa-mir-503-5p/PDCD4 axis was identified using online tools for detecting circRNA-associated