P21-activated kinase 4: a potent oncogene, molecular mechanisms and opportunities for targeted therapy

Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12935-025-04042-z. Article type: Review Article Keywords: PAK4, Inhibitor, Prognosis, Role, Signaling pathway Authors: Guojing Huang, Yalin Yang, Qian Luo, Xiaoqing Wang, Yifan Wang, Rong Liu, Wenting Liu, Shiwen Yan, Xiang Li Affiliations: https://ror.org/04ypx8c21grid.207374.50000 0001 2189 3846Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001 Henan China; https://ror.org/05ses6v92grid.459509.4Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Yangtze University, Jingzhou, 434023 Hubei China; https://ror.org/02dknqs67grid.506924.cChina-US (Henan)