Monoamine Oxidase B in Cancers: Implications for Therapeutics and Prognosis

Abstract Monoamine oxidase B (MAOB) is an enzyme implicated in various physiological and pathological processes, particularly in the context of cancer. This review comprehensively examines the metabolic functions of MAOB within its dual implications in tumorigenesis. MAOB is significantly involved in regulating the levels of monoamines, including dopamine, and its dysregulation is associated with neurodegenerative diseases and cancer progression. Elevated MAOB activity has been linked to increased oxidative stress, contributing to tumor growth and metastasis through enhanced glycolysis and mitochondrial