Development and validation of a necroptosis-related gene signature for predicting prognosis and immune infiltration in papillary thyroid cancer

Abstract Background: Papillary thyroid cancer (PTC) accounts for over 80–85% of all thyroid malignancies and presents a rising global incidence. Necroptosis plays a pivotal role in oncogenesis and immune regulation. However, the prognostic relevance of necroptosis-related genes (NRGs) in PTC remains inadequately explored. This study aims to construct a prognostic model for PTC based on NRGs and evaluate its predictive value for the prognosis of PTC patients. Methods: Using data from The Cancer Genome Atlas (TCGA) and the Gene Expression