B3GNT3 is an oncogenic and prognostic biomarker in human tumors via pan-cancer analysis combined with experimental validation

Abstract Background: Beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3) is a member of the glycosyltransferase family, which is widely distributed in the Golgi apparatus and plasma membrane. However, the role of B3GNT3 in human pan-cancer has not yet been systematically analyzed and evaluated. This study aims to assess the expression profiles of B3GNT3 in different types of cancers and its potential clinical significance through a pan-cancer analysis. Methods: Public data were derived from The Cancer Genome Atlas (TCGA) program and The Genotype-Tissue Expression (GTEx)