Piper auritum (Kunth) Fungal Endophytes: A Source of Metabolites to Inhibit the Formation of Advanced Glycation End Products

Abstract Excessive accumulation of advanced glycation end products (AGEs) is implicated in the development of non‐communicable diseases like diabetes, neurodegeneration, and cancer, among others. Inhibition of AGEs formation represents a promising therapeutic alternative for management of these diseases. This study explores 12 fungal endophytes from Piper auritum (Kunth) as sources of inhibitors of AGEs formation (in vitro). Extracts from Neopestalotiopsis and Diaporthe exhibited the strongest activity, reducing AGEs formation more than 60%. Chemical profiling of these extracts was performed by