Exploring the potential role of ADRB1 as a tumor suppressor gene and prognostic biomarker in pan-cancer analysis

Abstract Background: The β1-adrenergic receptor (β1-AR) is an important membrane receptor belonging to the G protein coupled receptors, encoded by ADRB1. Norepinephrine released by the sympathetic nerve activates β-adrenergic receptors. Compared with β2-adrenergic receptor (β2-AR), β1-AR has higher affinity for norepinephrine. However, the current research is mostly limited to the role of β2-AR in cancer development, and the effect and mechanism of β1-AR on cancer prognosis are still unclear. Methods: We analyzed ADRB1 expression in different types of cancer and