The regulatory role of PTTG1 in proliferation and migration of thyroid cancer
Abstract Purpose: To investigate the role of PTTG1 in thyroid cancer, focusing on its impact on proliferation, migration, and the regulation of p53-related signaling pathways. Methods: We analyzed PTTG1 expression in thyroid cancer samples by using the TCGA database and validated our findings in tissue samples and cell lines. Functional assays including knockdown experiments using shRNA, CCK-8 assays for proliferation, scratch wound healing and Transwell assays for migration, and in vivo tumorigenesis experiments in mice were conducted. Expression levels of
This article is available to registered members
Create a free account to access our full library of peer-reviewed research on medical cannabis.
Join — it's freeAlready a member? Log in