Solid State Synthesis of Hyaluronic Acid–Quercetin Conjugate: Sustainable Protocol to Improve the Biological Activity of Quercetin

Abstract Herein, a sustainable solid‐state procedure is employed for the synthesis of a water‐soluble molecule obtained by linking hyaluronic acid to the hydrophobic quercetin (HA‐QCT). The micellar self‐aggregation of the developed conjugate suggested its employment as a drug delivery nano‐system, considering the numerous biological activities of QCT. Indeed, the spectroscopic characterization (ultraviolet−visible and Fourier transform infrared) ensured that the QCT maintained its chemical integrity. In addition, a cytotoxicity test revealed that HA‐QCT can be employed as a biocompatible drug vehicle