Pan‑cancer analysis of oncogene SFXN1 to identify its prognostic and immunological roles in lung adenocarcinoma

Abstract As cancer incidence and mortality rates continue to rise, the urgency for research in this field has increased globally. Sideroflexin 1 (SFXN1), a pivotal member of the SFXN protein family, serves a crucial role in transporting serine to mitochondria and participates in one-carbon metabolism, thereby influencing cell proliferation and differentiation. While SFXN1 is linked to lung cancer and glioma, its role in other malignancies remains largely unexplored. Utilizing The Cancer Genome Atlas, Human Protein Atlas, Gene Expression Profiling Interactive