Stereoelectroencephalographic thermocoagulation in FLNA ‐positive heterotopia: Is it an effective treatment?

Abstract Periventricular nodular heterotopia (PVNH) is a neuronal migration disorder often associated with drug‐resistant epilepsy. The epileptogenic zone network (EZN) in PVNH is generally large, contraindicating surgery. Stereoelectroencephalography (SEEG) can be proposed to map the EZN and perform radiofrequency thermocoagulation (THC) with an efficacy rate of approximately 65%. There are genetic forms of PVNH, particularly with mutations in the filamin A gene (FLNA). However, data on SEEG‐guided THC in these patients still have not been described. We report four patients