DPH2 is a biomarker associated with cell death, immunity and prognosis based on pan-cancer analysis

Abstract Objective: DPH2, also known as DPH2L2, is one of two human genes similar to yeast dph2. One DPH2 variant has been linked to diphthamide syndrome, a disorder affecting ribosome function. While studies on DPH2 in a single cancer type have been documented, no comprehensive investigations of DPH2 across pan-cancer have been reported, its role in tumor pathogenesis and development remains unclear. Methods: The predictive significance and immune and biological roles of DPH2 in 33 different cancer types were investigated.