CD27 as a Diagnostic Biomarker and Its Role in Immune Heterogeneity and Predicting Clinical Drug Responses in Hashimoto’s Thyroiditis

Abstract Objective: To identify key genes and potential molecular mechanisms associated with Hashimoto’s thyroiditis (HT) to provide new insights for the development of diagnostic and therapeutic targets for this disease. Methods: Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were conducted to identify the differentially expressed genes (DEGs) associated with HT. A protein-protein interaction (PPI) network was used to obtain hub genes, with CD27 emerging as the key gene in HT. Gene Ontology (GO) analysis, Kyoto Encyclopedia of