TAJ-Net: a two-stage clustered cell segmentation network with adaptive joint learning of spatial and spectral information

Abstract Pulmonary adenocarcinoma is the primary cause of cancer-related death worldwide and pathological diagnosis is the “golden standard” based on the regional distribution of cells. Thus, regional cell segmentation is a key step while it is challenging due to the following reasons: 1) It is hard for pure semantic and instance segmentation methods to obtain a high-quality regional cell segmentation result; 2) Since the spatial appearances of pulmonary cells are very similar which even confuse pathologists, annotation errors are usually