Piers–Rubinsztajn reaction to unlock an 8-step synthesis of 7-hydroxy cannabidiol†

Abstract A scalable synthesis of 7-hydroxy cannabidiol (7-OH CBD), a primary metabolite of (−)-cannabidiol (CBD), is highly desirable, from an industrial point of view, to enable future clinical trials. A Piers–Rubinsztajn reaction was key to enable a mild deprotection and a concise synthesis of 7-OH CBD from commercially available CBD, in 31% overall yield. Authors: Emanuele Cocco ⚬, Debora Iapadre ⚬, Alessandro Brusa ⚬, Pietro Allegrini ⚬, Stephen P. Thomas ⚬, Fabio Pesciaioli ⚬, Armando Carlone ⚬ Affiliations: a Department