Effects of sex and pre-exposure on Δ9-tetrahydrocannabinol (THC) vapor self-administration in rats

Abstract Rationale: Animal models of cannabinoid self-administration are critical for advancing our understanding of the neurobiology of cannabis use and for developing medications for Cannabis Use Disorder. Use of vapor inhalation models have translational relevance, as the majority of human cannabis user do so by inhalation (e.g., smoking, vaporization). Methods: Adult male and female Sprague Dawley rats (N=96, 6–12 per sex/group) were pre-exposed to vaporized THC or vehicle (Veh; 100% propylene glycol). Rats were then trained to self-administer vapor puffs