Safety, Efficacy and Doxorubicin Pharmacokinetics During Cannabidiol/Cannabidiolic Acid Rich Hemp Oil Use in Dogs With Lymphoma Undergoing CHOP Chemotherapy

Abstract Background: The safety of oral cannabidiol (CBD) and cannabidiolic acid (CBDA)‐rich hemp oil supplementation in dogs with cancer receiving chemotherapy has not been investigated. Objectives: To evaluate the safety, tolerability, and influence on doxorubicin exposure over time of oral CBD/CBDA‐rich hemp oil supplementation in dogs diagnosed with high grade lymphoma undergoing CHOP chemotherapy. Animals: Client‐owned dogs diagnosed with lymphoma. Methods: Dogs were enrolled in this prospective, double‐blinded, randomized, placebo‐controlled clinical trial to receive either CBD/CBDA‐rich hemp oil capsules or