Differential effects of S-allyl cysteine and cannabidiol on enterocytic and plasma amyloid-β in db/db diabetic mice

Abstract Peripheral amyloid-beta (Aβ), including those in bloodstream and intestine, is implicated in the pathogenesis of Alzheimer’s disease (AD). Additionally, diabetes and insulin resistance are associated with the impairment of Aβ metabolism and an increased risk of developing cognitive decline and AD. Previous research has demonstrated the neuroprotective effects of cannabidiol (CBD) and S-allyl-cysteine (SAC); however, their impact on Aβ levels in the context of diabetes remains unexplored. 5-week-old diabetic db/db mice underwent 23 weeks of dietary interventions with SAC,