Prenatal and early postnatal cannabis exposure interactions with adolescent chronic stress on anxiety-like, depression-like, and risk-taking behaviour

Abstract Rationale: Low socioeconomic status people make up a majority of those who use cannabis during pregnancy. Both developmental cannabis exposure and developmental stress increase the risk of developing psychiatric disorders; however, the interaction of these factors has not been studied. Objectives: This study examined whether prenatal and early postnatal cannabis exposure (PPCE) impacted susceptibility to chronic adolescent stress in a dose- and environment-controlled animal model. Methods: Mouse dams orally consumed 5 mg/kg THC in whole cannabis oil daily from