Discovery of Pyrazoline Benzenesulfonamide Derivatives as Anticancer Agents: A Review

Abstract Pyrazoline benzenesulfonamide derivatives represent a distinctive class of heterocyclic compounds that synergistically combine the pharmacological versatility of the pyrazoline scaffold with the enzyme-inhibitory prowess of benzenesulfonamide moieties. These hybrids have emerged as promising candidates in anticancer drug discovery. This review systematically examines various synthetic strategies employed to prepare these derivatives, including classical Claisen–Schmidt condensation as well as modern ultrasound- and microwave-assisted protocols. These methods facilitate efficient structural diversification, incorporating a wide range of heterocyclic and aromatic substituents such as