ATOH1 and NPAS1 are immune related prognostic biomarkers in colorectal cancer
Abstract Background: Basic helix-loop-helix (bHLH) transcription factors are implicated in tumorigenesis, but their comprehensive role in colorectal cancer (CRC) remains unclear. This study aims to systematically characterize the bHLH family in CRC. Methods: Transcriptomic and clinical data from TCGA COAD/READ cohorts were analyzed as a discovery set and validated with GEO datasets (GSE39582, GSE17538). Differential expression, Kaplan-Meier survival, and Cox regression analyses identified prognostic bHLH genes. A prognostic risk model was constructed, and immune infiltration was assessed via TIMER2.0. Protein-protein
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