Role of glutathione disulfide reductase in colorectal cancer: a tumor suppressor
Abstract Background: Glutathione-disulfide reductase (GSR) was responsible for maintaining the supply of reduced glutathione, and was found to be abnormally expressed in a variety of cancers. There was an incomplete understanding regarding the roles of GSR in colorectal cancer (CRC) today. Methods: We used colorectal cancer tissues and cell lines to detect the function of GSR in CRC. We also used bioinformatics to analyze the related pathways of GSR in colorectal cancer. Results: GSR mRNA was down-regulated in CRC (p
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