Delta‐9‐Tetrahydrocannabinol (THC) Before Bedtime: Feasibility and Mechanistic Pilot Study on Sleep and Cardiac Autonomic Activity

Abstract Disordered sleep is a common reason individuals report using cannabis, yet the physiological effects of Δ9‐tetrahydrocannabinol (Δ9‐THC) on sleep and autonomic regulation remain incompletely understood. Early studies reported acute sleep‐promoting effects of Δ9‐THC, but chronic use has been associated with disrupted sleep and possible cardiovascular risk. This feasibility and mechanistic pilot study examined the influence of acute Δ9‐THC administration on sleep and cardiac parasympathetic activity in adults with and without regular cannabis use. Nine individuals with regular cannabis use